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What’s the best driving route from St. Louis to Gulf Shores?

I’m driving down to the Gulf Coast area to visit family, and I want to make sure I get there in as little time as possible. What’s the best driving route from St. Louis to Gulf Shores?

avatar
Amber Reed · Updated on
Reviewed by Shannon Martin, Licensed Insurance Agent.
The Gulf Coast is a gorgeous part of the country, and you’ll be heading through some beautiful scenery on the way!
The best driving route from
St Louis
to
Gulf Shores
is via I-55 S and US-45.
This route will take you about 11.5 hours to complete and cover around 698 miles. If you want to go through
Memphis
, then you can stay on I-55 S a bit longer before it connects back with US-45. This route is approximately the same amount of miles, but may result in a longer travel time as there is the potential to hit traffic in the city.
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