Powered by a mighty 3.5-liter V6 engine, the 2006 Acura MDX boasts 253 horsepower and 250 lb-ft of torque that can soar from zero to 60 in less than eight seconds. Of course, you’ll want to drive more conservatively if you want to keep gas costs down. A five-speed automatic transmission is standard, so you can expect an EPA rating of 15/21/17 mpg for city/highway/combined driving with premium gasoline.