What’s the best route to Myrtle Beach from Harrisburg, PA?

I have some friends who are going to be in South Carolina next summer, and they’ve convinced me to drive down to meet them there. What’s the best route to Myrtle Beach from Harrisburg, PA?

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Answer provided by
Amber Reed
Answered on May 12, 2022
Myrtle Beach is a beautiful spot to visit, so you’ll be glad you made the trip!
The best route to Myrtle Beach from Harrisburg, PA is via I-95 South.
You’ll drive on US 15 S for about 70 miles before you take I-95 via Interstates 270 and 495 South. Stay on I-95 for about 400 miles, and then you’ll take US 74 and US 701 into the Myrtle Beach area. The entire trip totals about 8.5 hours of driving.
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