What’s the best route to drive from Chicago to Los Angeles?

I live in Chicago and I am heading to Los Angeles for a month to visit some friends. I’d love to have a car out there, so I’m thinking about driving—what’s the best way to get there?

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Answer provided by
Andrea Barrett
Answered on May 12, 2022
Route 66 from Chicago to Los Angeles is the best way to get between the two cities. The route covers 2,451 miles and passes through every landscape you can imagine—farmland, mountains, desert, cities, and everything in between.
Here’s how to get there:
  • Get on I-55 S/Stevenson Expy from S Clark St
  • Continue on I-55 S
  • Take exit 40B W for I-44 W
  • Take exit 34 for I-44 W/US-412 W toward OK-66/Tulsa
  • Merge onto I-44/US-412 W
  • Take the exit onto I-40 W toward Amarillo
  • Merge onto I-15 S
  • Stay on I-15 S, follow signs for Los Angeles/San Diego
  • Take exit 115A to merge onto CA-210 W toward Pasadena
  • Take the Interstate 605 S exit
  • Take exit 22 to merge onto I-10 W toward Los Angeles
  • Stay on I-10 W, follow signs for Valley Blvd/Long Bch/I-710
  • Continue on San Bernardino Fwy, follow signs for US 101/Los Angeles/I-5 N/Sacramento
  • Take exit 2B toward Alameda St/Union Station
Along the way, you’ll pass through 8 states, and there’s plenty to see and do in each. Here are some of the top cities to check out along the way:
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