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What’s the best driving route from Cincinnati to Myrtle Beach?
We’re taking a family vacation to Myrtle Beach this summer and plan to drive and check out some kid-friendly stops. What’s the best route to get there from Cincinnati?
Andrea Barrett · Updated on
Reviewed by Shannon Martin, Licensed Insurance Agent.
What a fun trip! The best route from Cincinnati to Myrtle Beach is along I-75 S, covering 660 miles over 10 hours and 13 minutes.
Here’s how to get there:
- Merge onto I-71 S via the ramp to I-75 S/Louisville/Lexington
- Continue on I-275 S, follow signs for I-640 E/Asheville
- Merge onto I-640 E toward Asheville
- Continue on US-74 E, follow signs for I-26 E/Hendersonville/Spartanburg
- Merge onto I-26 E/US-74 E
- Take exit 107B to merge onto I-20 E toward Florence
- Take exit 141A to merge onto I-95 N toward Fayetteville
- Take exit 170 to merge onto SC-327 S
- Slight left toward State Rd S-21-24
- Turn left onto US-301 N/US-76 E
- Continue onto SC-576
- Merge onto SC-41 ALT S/S Hwy 501 S
- Follow US-501 S into Myrtle Beach
During your travels, there are plenty of fun activities in the states you’ll pass through:
Before you head out with your kids in tow, make sure you have a solid insurance policy that keeps you protected on the road. Nothing spells a buzzkill like car damage without the proper coverage. But when you shop with
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- Gregory R.
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