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What is the best route from St. Louis to Pensacola?

I’m based in Missouri but I’m getting ready to go to a big family reunion party that happens every five years. This time it’s being held at my grandparents’ house in Florida. If I were to drive there, what’s the best route to get from St. Louis to Pensacola?

avatar
Mary Cahill · Updated on
Reviewed by Shannon Martin, Licensed Insurance Agent.
You gotta love when the family comes from near and far to gather round. The best route from
St. Louis
to
Pensacola
is via highways I-55 South and US-45.
The trip should take a total of 11 hours and 2 minutes. The journey going one way is 703.2 miles.
With a drive of this length, you’ll definitely want to stop halfway—if not overnight. The closest major city to the halfway point is
Memphis
, Tennessee. Or if you’d rather bypass the big city, you could get some rest in
Tupelo
Mississippi.
When you take on a long drive, safety is top priority—and when it comes to staying safe, one of the best things you can do is get good
car insurance
.
To get the best price with minimal time and effort, just download
Jerry
, the No. 1-rated car insurance app. With Jerry’s expert assistance, you can save hundreds on your car insurance in minutes—with just a few clicks of a button.
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