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What is the best route from Knoxville, Tennessee to Branson, Missouri?

My daughter just bought her first home and is hosting a housewarming party. I’m so excited to visit, but I’m based in Knoxville and have never driven to the part of Missouri where she lives. I’d like to know what the best route is from my home in Knoxville, Tennessee to Branson, Missouri?

avatar
Mary Cahill · Updated on
Reviewed by Shannon Martin, Licensed Insurance Agent.
It’s fun to visit new places—once you know how to get there! The best route from
Knoxville
, Tennessee to
Branson
, Missouri is via highways I-40 West and US-60 West.
The one-way drive will take about 9 hours and 45 minutes at a length of 632 miles. If you’d like to stop along the way—and you probably will—the midway point is Palmersville, Tennessee.
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