That sounds really frustrating! A Ford E-350 transmission replacement cost may run you upwards of $4,000 for a new part, but you could pay less if the transmission can be rebuilt.
Transmission repairs are really expensive, unfortunately. Even if you drive a newer E-350, transmission replacement costs are still exorbitant.
A seriously damaged transmission must be replaced with a new part, and this is the most expensive option. Minor damage might be fixable if your mechanic can rebuild the transmission. This is still really costly and complicated, but it is slightly less expensive than buying a brand new transmission.
Good luck with your van—we’re rooting for you!