Generally speaking, you can expect a Ford E-250 transmission replacement to cost between $4000 and $5,300, depending on your location, the replacement parts you’re able to acquire, and the specific automotive repair shop you visit.
The parts associated with replacing a Ford E-250 transmission cost somewhere between $2,500 and $3500, though you can probably find cheaper ones if you buy the parts used.
The other $1,500 to $1,800 goes towards paying for the mechanic’s labor, as replacing your Ford E-250’s transmission is a complex and lengthy process, one that may take upwards of a day to complete.