The first and most obvious case is one where losing your driver’s license affects your ability to do your job. If you’re a bus driver, delivery driver, or chauffeur, you can’t drive without a valid license and your employer could let you go. You may be able to keep your employment by asking to be transferred to a desk job while you work on reinstating your license.
Indirectly, a DUI conviction or reckless driving charge (and the accompanying license suspension) may also cause your employer to question your judgment. Your reputation could suffer if your job depends on trust and working with the vulnerable, like a medical, educational, or caretaking career.